The plague.

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"The bubonic plague is an epidemic disease causing a high rate of mortality; a contagious disease that is caused by a bacterium (Yersinia pestis) and that occurs in bubonic, pneumonic and septicemic forms. It is also a cause of irritation, or a sudden unwelcome outbreak." Millions of people and their families have had a close encounter with this Black Death with nothing good to come from it. The nasty disease comes right in and takes …

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…as biohazard. www.biohazardnew.net. October 20, 2002. Platt, Colin. King Death: The Black Death and its aftermath in late-medieval England. Toronto; Buffalo: University of Toronto Press, c 1997. State University of New York at Binghamton Center for Medieval Studies. The Black Death: The impact of the fourteenth-century Plague. Medieval & Renaissance texts & studies, ISBN January 1983. TED Case Studies. www.american.edu/projects/mandala/TED/Bubonic.HTM#r6. October 8, 2002. Ziegler, Phillip. The Black Death. Harper Collins, June 1971.