Phencyclidine - The dust of angles,Emphasis on molecular mechanisims of PCP

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The Dawn of a New Age April, 1956 : The pharmaceutical company Parke & Davis first synthesize what they believe to be the perfect anesthetic (Souza, 1995). When administered to patients, it causes a completely dissociative state, with no significant respiratory or cardiovascular depression. Patients appear to be awake, eyes open, breathing normally.but are unaware of their surroundings or the procedures being performed upon them (Souza, 1995). Indeed, this is the perfect drug. Unfortunately, like all good things, …

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…amp; Stillman, R.C. (1978). PCP-Phencylidine Abuse: An appraisal. New York, NY: National Institute on Drug Abuse. Restak, R.M. (1994). Receptors. New York, N.Y: Bantam Books. Souza, Errol B., & Clouet, D., & London, E.D. (1993). Sigma, PCP, and NMDA Receptors. New York, NY: National Institute on Drug Abuse. Svensson, T.H. (1995). Mode of action of atypical neuroleptics in relation to the phencyclidine model of schizophrenia. Journal of Clinical Psychopharmacology. (Vol. 15) 11S-18S