Cystic Fibrosis

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Cystic fibrosis (CF) is a chronic, progressive, and frequently fatal genetic disease of the body's mucus glands. CF primarily affects the respiratory and digestive systems in children and young adults. Sweat glands and the reproductive system also are usually involved. On average, individuals with CF have a lifespan of about 30 years. CF is an autosomal recessive disorder caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene. Heterozygous carriers are asymptomatic. Two altered …

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…of CF, although several drug-based approaches are being investigated. In the meantime, doctors can only ease the symptoms of CF or slow the progress of the disease so the patient's quality of life is improved. This is achieved by antibiotic therapy combined with treatments to clear the thick mucus from the lungs. The therapy is tailored to the needs of each patient. For patients whose disease is very advanced, lung transplantation may be an option.